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Humane Papillomviren
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Humane Papillomviren

Aktuelle Publikationen des Instituts zum Thema Humane Papillomviren - HPV (chronologisch sortiert)


Oette M, Wieland U, Schünemann M, Haes J, Reuter S, Jensen BE, Sagir A, Pfister H, Häussinger D. (2017 ) Anal chromoendoscopy using gastroenterological video-endoscopes: A new method to perform high resolution anoscopy for diagnosing intraepithelial neoplasia and anal carcinoma in HIV-infected patients. Z Gastroenterol. 55(1):23-31

Herberhold S, Hellmich M, Panning M, Bartok E, Silling S, Akgül B, Wieland U. Human polyomavirus and human papillomavirus prevalence and viral load in non-malignant tonsillar tissue and tonsillar carcinoma. Med Microbiol Immunol. 2016 Nov 10. [Epub ahead of print]

Kreuter A, Siorokos C, Oellig F, Silling S, Pfister H, Wieland U. (2016) High-Grade Dysplasia in Anogenital Warts of HIV-Positive Men. JAMA Dermatol. 152(11):1225-1230.

Rödel F, Martin D, Helmke C, Balermpas P, Fokas E, Wieland U, Rave-Fränk M, Kitz J, Matthess Y, Raab M, Strebhardt K, Rödel C. (2016) Polo-like kinase 3 and phosphoT273 caspase-8 are associated with improved local tumor control and survival in patients with anal carcinoma treated with concomitant chemoradiotherapy. Oncotarget. 7(33):53339-53349.

Fuchs W, Wieland U, Skaletz-Rorowski A, Brockmeyer NH, Swoboda J, Kreuter A, Michalik C, Potthoff A; Competence Network for HIV/AIDS. (2016) The male ScreenING Study: prevalence of HPV-related genital and anal lesions in an urban cohort of HIV-positive men in Germany. J Eur Acad Dermatol Venereol. 30(6):995-1001

Fuchs W, Kreuter A, Hellmich M, Potthoff A, Swoboda J, Brockmeyer NH, Wieland U (2016). Asymptomatic anal sexually transmitted infections in HIV-positive men attending anal cancer screening. Br J Dermatol. 174(4):831-838

Kreuter A, Esser S, Wieland U (2015). Prevention of Anal Carcinoma. Dtsch Arztebl Int. 112(43): 739.

Wieland U, Hellmich M, Wetendorf J, Potthoff A, Höfler D, Swoboda J, Fuchs W, Brockmeyer N, Pfister H, Kreuter A. (2015) Smoking and anal high-risk human papillomavirus DNA loads in HIV-positive men who have sex with men. Int J Med Microbiol. 305(7):689-96.

Wieland U, Brockmeyer NH, Kreuter A. (2015) A 9-Valent HPV Vaccine in Women. N Engl J Med. 372(26): 2566.

Kreuter A, Esser S, Wieland U (2015). Anal cancer screening. J Am Acad Dermatol. 72(2): 367-368.

Olthof NC, Huebbers CU, Kolligs J, Henfling M, Ramaekers FC, Cornet I, van Lent-Albrechts JA, Stegmann AP, Silling S, Wieland U, Carey TE, Walline HM, Gollin SM, Hoffmann TK, de Winter J, Kremer B, Klussmann JP, Speel EJ (2015). Viral load, gene expression and mapping of viral integration sites in HPV16-associated HNSCC cell lines. Int J Cancer 136(5): E207-218.

Rödel F, Wieland U, Fraunholz I, Kitz J, Rave-Fränk M, Wolff HA, Weiss C, Wirtz R, Balermpas P, Fokas E, Rödel C (2015). Human papillomavirus DNA load and p16(INK4a) expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy. Int J Cancer 136(2): 278-288.

Marcuzzi GP, Awerkiew S, Hufbauer M, Schädlich L, Gissmann L, Eming S, Pfister H (2014). Tumor prevention in HPV8 transgenic mice by HPV8-E6 DNA vaccination. Med Microbiol Immunol. 203(3): 155-163.

Wieland U, Kreuter A, Pfister H (2014). Human papillomavirus and immunosuppression. Curr Probl Dermatol. 45: 154-165.

Olthof NC, Speel EJ, Kolligs J, Haesevoets A, Henfling M, Ramaekers FC, Preuss SF, Drebber U, Wieland U, Silling S, Lam WL, Vucic EA, Kremer B, Klussmann JP, Huebbers CU (2014). Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression. PLoS One. 9(2): e88718.

Silling S, Wieland U, Werner M, Pfister H, Potthoff A, Kreuter A (2014). Resolution of novel human papillomavirus-induced warts after HPV vaccination. Emerg Infect Dis. 20(1): 142-145.

Mooren JJ, Gültekin SE, Straetmans JM, Haesevoets A, Peutz-Kootstra CJ, Huebbers CU, Dienes HP, Wieland U, Ramaekers FC, Kremer B, Speel EJ, Klussmann JP (2014). P16(INK4A) immunostaining is a strong indicator for high-risk-HPV-associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low-risk-HPV-infection in head and neck papillomas and laryngeal dysplasias. Int J Cancer. 134(9): 2108-2117.

Hufbauer M, Biddle A, Borgogna C, Gariglio M, Doorbar J, Storey A, Pfister H, Mackenzie I, Akgül B (2013). Expression of betapapillomavirus oncogenes increases the number of keratinocytes with stem cell-like properties. J Virol. 87(22): 12158-12165.

Kreuter A, Wieland U, Hampl M (2013). Recurrent high-risk human papillomavirus-induced anogenital dysplasia in chronic idiopathic CD4+ T lymphocytopaenia. Acta Derm Venereol. 93(6): 759-760.

Wieland U, Kreuter A (2013). One step towards standardised management of anal dysplasia. Lancet Oncol. 14(4): 273-274.


Neale RE, Weissenborn S, Abeni D, Bouwes Bavinck JN, Euvrad S, Feltkamp MC, Green AC, Harwood CA, de Koning MN, Naldi L, Nindl I, Pawlita M, Proby C, Quint W, Waterboer T, Wieland U, Pfister HJ (2013). Human Papilloma Virus load in eyebrow hair follicles and risk of cutaneous squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 22: 719-727.

Kreuter A, Wieland U (2013). Lack of efficacy in treating condyloma acuminata and preventing recurrences with the recombinant quadrivalent human papillomavirus vaccine in a case series of immunocompetent patients. J Am Acad Dermatol 68(1): 179-180.

Wieland U, Stuecker M, Kreuter A(2012). "HPV vaccine against anal intraepithelial neoplasia." N Engl J Med 366(4): 378; author reply 378-379.

Silling S, Kreuter A, Hellmich M, Swoboda J, Pfister H, Wieland U (2012). "Human papillomavirus oncogene mRNA testing for the detection of anal dysplasia in HIV-positive men who have sex with men." J Clin Virol 53(4): 325-331.

Lazic, D., F. Alborzi, G. P. Marcuzzi, P. Angel, J. Hess, H. Pfister and B. Akgül (2011). "Enhanced StefinA and Sprr2 expression during papilloma formation in HPV8 transgenic mice." J Dermatol Sci 62(2): 84-90.

Akgül, B., R. Garcia-Escudero, C. Ekechi, G. Steger, H. Navsaria, H. Pfister and A. Storey (2011). "The E2 protein of human papillomavirus type 8 increases the expression of matrix metalloproteinase-9 in human keratinocytes and organotypic skin cultures." Med Microbiol Immunol 200(2): 127-135.

Akgül, B., B. Bauer, P. Zigrino, A. Storey, C. Mauch and H. Pfister (2011). "Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas." J Gen Virol 92(Pt 2): 395-401.

Schröer, N., J. Pahne, B. Walch, C. Wickenhauser and S. Smola (2011). "Molecular pathobiology of human cervical high-grade lesions: paracrine STAT3 activation in tumor-instructed myeloid cells drives local MMP-9 expression." Cancer Res 71(1): 87-97.

Oldak, M., L. Tolzmann, A. Wnorowski, M. J. Podgorska, S. Silling, R. Lin, J. Hiscott, C. S. Muller, T. Vogt, H. Smola and S. Smola (2011). "Differential regulation of human papillomavirus type 8 by interferon regulatory factors 3 and 7." J Virol 85(1): 178-188.

Weissenborn, S., R. E. Neale, T. Waterboer, D. Abeni, J. N. Bavinck, A. C. Green, C. A. Harwood, S. Euvrard, M. C. Feltkamp, M. N. de Koning, L. Naldi, W. G. Quint, G. Tessari, C. M. Proby, U. Wieland and H. Pfister (2011). "Beta-papillomavirus DNA loads in hair follicles of immunocompetent people and organ transplant recipients." Med Microbiol Immunol 201(2): 117-125.

Proby, C. M., C. A. Harwood, R. E. Neale, A. C. Green, S. Euvrard, L. Naldi, G. Tessari, M. C. Feltkamp, M. N. de Koning, W. G. Quint, T. Waterboer, M. Pawlita, S. Weissenborn, U. Wieland, H. Pfister, E. Stockfleth, I. Nindl, D. Abeni, J. T. Schegget and J. N. Bouwes Bavinck (2011). "A case-control study of betapapillomavirus infection and cutaneous squamous cell carcinoma in organ transplant recipients." Am J Transplant 11(7): 1498-1508.

Hufbauer, M., D. Lazic, M. Reinartz, B. Akgül, H. Pfister and S. J. Weissenborn (2011). "Skin tumor formation in human papillomavirus 8 transgenic mice is associated with a deregulation of oncogenic miRNAs and their tumor suppressive targets." J Dermatol Sci 64(1): 7-15.

Kreuter, A. and U. Wieland (2011). "Images in clinical medicine. Giant condyloma acuminatum of Buschke and Lowenstein." N Engl J Med 365(17): 1624.

Kreuter, A., M. F. Meyer and U. Wieland (2011). "Occurrence of penile intraepithelial neoplasia following adalimumab treatment for psoriatic arthritis." Arch Dermatol 147(8): 1001-1002.

Kreuter, A., A. Potthoff, N. H. Brockmeyer, T. Gambichler, J. Swoboda, M. Stucker, M. Schmitt, H. Pfister and U. Wieland (2010). "Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany." Br J Dermatol 162(6): 1269-1277.

Kreuter, A., M. Jesse, A. Potthoff, N. H. Brockmeyer, T. Gambichler, M. Stucker, F. G. Bechara, H. Pfister and U. Wieland (2010). "Expression of proliferative biomarkers in anal intraepithelial neoplasia of HIV-positive men." J Am Acad Dermatol 63(3): 490-498.

De Andrea, M., M. Ritta, M. M. Landini, C. Borgogna, M. Mondini, F. Kern, K. Ehrenreiter, M. Baccarini, G. P. Marcuzzi, S. Smola, H. Pfister, S. Landolfo and M. Gariglio (2010). "Keratinocyte-specific stat3 heterozygosity impairs development of skin tumors in human papillomavirus 8 transgenic mice." Cancer Res 70(20): 7938-7948.

Hufbauer, M., D. Lazic, B. Akgul, J. L. Brandsma, H. Pfister and S. J. Weissenborn (2010). "Enhanced human papillomavirus type 8 oncogene expression levels are crucial for skin tumorigenesis in transgenic mice." Virology 403(2): 128-136.

Akgul, B., N. Bostanci, K. Westphal, I. Nindl, H. Navsaria, A. Storey and H. Pfister (2010). "Human papillomavirus 5 and 8 E6 downregulate interleukin-8 secretion in primary human keratinocytes." J Gen Virol 91(Pt 4): 888-892.

Purdie, K. J., C. Pourreyron, H. Fassihi, R. Cepeda-Valdes, J. W. Frew, A. Volz, S. J. Weissenborn, H. Pfister, C. M. Proby, L. Bruckner-Tuderman, D. F. Murrell, J. C. Salas-Alanis, J. A. McGrath, I. M. Leigh, C. A. Harwood and A. P. South (2010). "No evidence that human papillomavirus is responsible for the aggressive nature of recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma." J Invest Dermatol 130(12): 2853-2855.

Klingenberg, B., H. C. Hafkamp, A. Haesevoets, J. J. Manni, P. J. Slootweg, S. J. Weissenborn, J. P. Klussmann and E. J. Speel (2010). "p16 INK4A overexpression is frequently detected in tumour-free tonsil tissue without association with HPV." Histopathology 56(7): 957-967.

Bouwes Bavinck, J. N., R. E. Neale, D. Abeni, S. Euvrard, A. C. Green, C. A. Harwood, M. N. de Koning, L. Naldi, I. Nindl, M. Pawlita, H. Pfister, C. M. Proby, W. G. Quint, J. ter Schegget, T. Waterboer, S. Weissenborn and M. C. Feltkamp (2010). "Multicenter study of the association between betapapillomavirus infection and cutaneous squamous cell carcinoma." Cancer Res 70(23): 9777-9786.

Mallitt, K. A., P. O'Rourke, J. N. Bouwes Bavinck, D. Abeni, M. N. de Koning, M. C. Feltkamp, A. C. Green, W. G. Quint, K. M. Michael, M. Pawlita, H. Pfister, S. Weissenborn, T. Waterboer and R. E. Neale (2010). "An analysis of clustering of betapapillomavirus antibodies." J Gen Virol 91(Pt 8): 2062-2067.

Gross, G., L. Gissmann, P. Hillemanns, H. Ikenberg, A. M. Kaufmann, K. U. Petry, H. Pfister, P. Schneede, A. Schneider and S. Smola (2010). "[Prevention of HPV-associated neoplasias by vaccination - short version of the German S3 (level 3) guideline]." Dtsch Med Wochenschr 135(21): 1083-1086.

Oldak, M., R. B. Maksym, T. Sperling, M. Yaniv, H. Smola, H. J. Pfister, J. Malejczyk and S. Smola (2010). "Human papillomavirus type 8 E2 protein unravels JunB/Fra-1 as an activator of the beta4-integrin gene in human keratinocytes." J Virol 84(3): 1376-1386.

Weissenborn, S. J., U. Wieland, M. Junk and H. Pfister (2010). "Quantification of beta-human papillomavirus DNA by real-time PCR." Nat Protoc 5(1): 1-13.

Kreuter, A., T. Gambichler, H. Pfister and U. Wieland (2009). "Diversity of human papillomavirus types in periungual squamous cell carcinoma." Br J Dermatol 161(6): 1262-1269.

Kreuter, A., M. Skrygan, T. Gambichler, N. H. Brockmeyer, M. Stucker, C. Herzler, A. Potthoff, P. Altmeyer, H. Pfister and U. Wieland (2009). "Human papillomavirus-associated induction of human beta-defensins in anal intraepithelial neoplasia." Br J Dermatol 160(6): 1197-1205.

Kreuter, A. and U. Wieland (2009). "Human papillomavirus-associated diseases in HIV-infected men who have sex with men." Curr Opin Infect Dis 22(2): 109-114.

Marcuzzi, G. P., M. Hufbauer, H. U. Kasper, S. J. Weissenborn, S. Smola and H. Pfister (2009). "Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding." J Gen Virol 90(Pt 12): 2855-2864.

Westphal, K., B. Akgul, A. Storey and I. Nindl (2009). "Cutaneous human papillomavirus E7 type-specific effects on differentiation and proliferation of organotypic skin cultures." Cell Oncol 31(3): 213-226.

Akgul, B., P. Zigrino, D. Frith, S. Hanrahan and A. Storey (2009). "Proteomic analysis reveals the actin cytoskeleton as cellular target for the human papillomavirus type 8." Virology 386(1): 1-5.

Waterboer, T., R. Neale, K. M. Michael, P. Sehr, M. N. de Koning, S. J. Weissenborn, F. Sampogna, D. Abeni, A. C. Green, J. N. Bouwes Bavinck and M. Pawlita (2009). "Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia." J Gen Virol 90(Pt 8): 1986-1998.

Klussmann, J. P., J. J. Mooren, M. Lehnen, S. M. Claessen, M. Stenner, C. U. Huebbers, S. J. Weissenborn, I. Wedemeyer, S. F. Preuss, J. M. Straetmans, J. J. Manni, A. H. Hopman and E. J. Speel (2009). "Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications." Clin Cancer Res 15(5): 1779-1786.

Dell'Oste, V., B. Azzimonti, M. De Andrea, M. Mondini, E. Zavattaro, G. Leigheb, S. J. Weissenborn, H. Pfister, K. M. Michael, T. Waterboer, M. Pawlita, A. Amantea, S. Landolfo and M. Gariglio (2009). "High beta-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis." J Invest Dermatol 129(4): 1026-1034.

Borgogna, C., E. Zavattaro, V. Dell'Oste, M. Mondini, G. Valente, E. Colombo, S. Weissenborn, G. Leigheb, S. Landolfo and M. Gariglio (2009). "No indications for HPV involvement in the hypertrophic skin lesions of a Darier disease case without ATP2A2 gene mutations." J Cutan Pathol 36(9): 1005-1009.

Dole, V. S., H. Smola, S. Dooley, H. M. Said, M. Oldak, H. J. Pfister and S. Smola (2009). "The adenoviral E1A oncoprotein activates the Smad7 promoter: requirement of a functional E-box." Int J Oncol 35(6): 1493-1498.

Pathirana, D., P. Hillemanns, K. U. Petry, N. Becker, N. H. Brockmeyer, R. Erdmann, L. Gissmann, H. Grundhewer, H. Ikenberg, A. M. Kaufmann, J. Klusmann, I. Kopp, H. Pfister, B. Rzany, P. Schneede, A. Schneider, S. Smola, N. Winter-Koch, P. Wutzler and G. Gross (2009). "Short version of the German evidence-based Guidelines for prophylactic vaccination against HPV-associated neoplasia." Vaccine 27(34): 4551-4559.

Weissenborn, S. J., R. Neale, M. N. de Koning, T. Waterboer, D. Abeni, J. N. Bouwes Bavinck, U. Wieland and H. J. Pfister (2009). "Prevalence and multiplicity of cutaneous beta papilloma viruses in plucked hairs depend on cellular DNA input." J Virol Methods 161(2): 280-283.

de Koning, M. N., S. J. Weissenborn, D. Abeni, J. N. Bouwes Bavinck, S. Euvrard, A. C. Green, C. A. Harwood, L. Naldi, R. Neale, I. Nindl, C. M. Proby, W. G. Quint, F. Sampogna, J. ter Schegget, L. Struijk, U. Wieland, H. J. Pfister and M. C. Feltkamp (2009). "Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma." J Gen Virol 90(Pt 7): 1611-1621.

Weissenborn, S. J., M. N. De Koning, U. Wieland, W. G. Quint and H. J. Pfister (2009). "Intrafamilial transmission and family-specific spectra of cutaneous betapapillomaviruses." J Virol 83(2): 811-816.

Kreuter, A., S. Bischoff, M. Skrygan, U. Wieland, N. H. Brockmeyer, M. Stucker, P. Altmeyer and T. Gambichler (2008). "High association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides." Arch Dermatol 144(8): 1011-1016.

Kreuter, A., N. H. Brockmeyer, P. Altmeyer and U. Wieland (2008). "Anal intraepithelial neoplasia in HIV infection." J Dtsch Dermatol Ges 6(11): 925-934.

Kreuter, A., B. Hochdorfer, N. H. Brockmeyer, P. Altmeyer, H. Pfister and U. Wieland (2008). "A human papillomavirus-associated disease with disseminated warts, depressed cell-mediated immunity, primary lymphedema, and anogenital dysplasia: WILD syndrome." Arch Dermatol 144(3): 366-372.

Kreuter, A., A. Potthoff, N. H. Brockmeyer, T. Gambichler, M. Stucker, P. Altmeyer, J. Swoboda, H. Pfister and U. Wieland (2008). "Imiquimod leads to a decrease of human papillomavirus DNA and to a sustained clearance of anal intraepithelial neoplasia in HIV-infected men." J Invest Dermatol 128(8): 2078-2083.

Drebber, U., S. F. Preuss, H. U. Kasper, U. Wieland and H. P. Dienes (2008). "Postoperative fulminant varicella zoster virus hepatitis with fatal outcome: a case report." Z Gastroenterol 46(1): 45-47.

Pfefferle, R., G. P. Marcuzzi, B. Akgul, H. U. Kasper, F. Schulze, I. Haase, C. Wickenhauser and H. Pfister (2008). "The human papillomavirus type 8 E2 protein induces skin tumors in transgenic mice." J Invest Dermatol 128(9): 2310-2315.

Preuss, S. F., A. Weinell, M. Molitor, M. Stenner, R. Semrau, U. Drebber, S. J. Weissenborn, E. J. Speel, C. Wittekindt, O. Guntinas-Lichius, T. K. Hoffmann, G. D. Eslick and J. P. Klussmann (2008). "Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer." Br J Cancer 98(3): 627-632.

Eming, S., H. Smola, B. Hartmann, G. Malchau, R. Wegner, T. Krieg and S. Smola-Hess (2008). "The inhibition of matrix metalloproteinase activity in chronic wounds by a polyacrylate superabsorber." Biomaterials 29(19): 2932-2940.

Kreuter, A., N. H. Brockmeyer, S. J. Weissenborn, T. Gambichler, M. Stucker, P. Altmeyer, H. Pfister and U. Wieland (2008). "Penile intraepithelial neoplasia is frequent in HIV-positive men with anal dysplasia." J Invest Dermatol 128(9): 2316-2324.